Example : Everyone was aware of the approaching doom but was helpless to avoid it.
That's unfortunate but it isn't the end of the world.

Synonyms : day of reckoning, doomsday, end of the world

Example : She was destined to become a great pianist.

Synonyms : designate, destine, fate

Example : He was condemned to ten years in prison.

Synonyms : condemn, sentence

Example : This decision will doom me to lose my position.